There is a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent suffering transmission and generate analgesia. Thus, medicines like clonidine that target alpha-2 receptors can impact the transmission of soreness. This doc doesn't have all attainable interactions. https://www.proleviate.com/post/the-new-pain-killer-conolidine